3D confocal laser-scanning microscopy for large-area imaging of the corneal subbasal nerve plexus
نویسندگان
چکیده
منابع مشابه
Mapping the corneal sub-basal nerve plexus in keratoconus by in vivo laser scanning confocal microscopy.
PURPOSE To produce a two-dimensional reconstruction map of the living corneal sub-basal nerve plexus in keratoconus with in vivo confocal microscopy. METHODS Four eyes of four subjects with keratoconus were examined by slit lamp biomicroscopy, Orbscan II slit-scanning elevation topography (Bausch & Lomb Surgical, Rochester, NY), and laser scanning in vivo confocal microscopy with the Heidelbe...
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PURPOSE We established a baseline value for central corneal subbasal nerve density in a large, healthy cohort. METHODS A total of 106 healthy volunteers (207 eyes) underwent full ophthalmic examination, including laser-scanning in vivo confocal microscopy (IVCM) of the central cornea. Images of the corneal subbasal nerve plexus were acquired and analyzed based on defined criteria. Nerve traci...
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PURPOSE We examined the age-dependent alterations and longitudinal course of subbasal nerve plexus (SNP) morphology in healthy individuals. METHODS Laser-scanning corneal confocal microscopy, ocular screening, and health and metabolic assessment were performed on 64 healthy participants at baseline and at 12-month intervals for 3 years. At each annual visit, eight central corneal images of th...
متن کاملImage reconstruction of the subbasal nerve plexus with in vivo confocal microscopy.
PURPOSE To overcome the anterior corneal mosaic (ACM) phenomenon in in vivo confocal laser scanning microscopy (CLSM) and to reconstruct undistorted images of the subbasal nerve plexus (SNP), facilitating morphometric analysis in the presence of ACM ridges. METHODS CLSM was performed in five healthy volunteers. An original image processing algorithm based on phase correlation was used to anal...
متن کاملReal-time mapping of the subepithelial nerve plexus by in vivo confocal laser scanning microscopy.
AIM To produce two-dimensional reconstruction maps of the subepithelial nerve plexus (SEP) in living cornea by in vivo laser scanning confocal microscopy in real time. METHODS In vivo confocal laser scanning microscopy (Heidelberg Retinal Tomograph II in conjunction with the Rostock Cornea Module) was performed on normal eyes (n=6) and eyes after laser-assisted in situ keratomileusis (LASIK) ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-25915-6